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Synthetic Fluorination Methodology
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Graduate and Postdoctoral Work
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Ryan Altman
Our Team
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Synthetic Fluorination Methodology
Medicinal and Biological Chemistry
Folder: Publications
Back
All Publications
Synthetic Organic Methodology
Medicinal and Biological Chemistry
Reviews
Graduate and Postdoctoral Work
Book Chapters and Minor Works
Ryan Altman
Our Team
Links
2020 to Present, Synthetic Organic Methodology, Aromatization Altmaniacs 9/9/26 2020 to Present, Synthetic Organic Methodology, Aromatization Altmaniacs 9/9/26

66. Deoxytrifluoromethylation/Aromatization to Access Highly Substituted Fluoroalkyl Arenes Under Milder Aromatization Conditions

Bhattarai, P. B.; Zhao, A. Y.; Wise, J. W.; Cowper, N. G. W.; Gilbert, M. M.; Morrill, W. H.; Tao, D. J.; Goel K.; Altman, R. A.*

Manuscript Submitted.

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2020 to Present, Medicinal and Biological Chemistry, Delta Opioid Receptor Altmaniacs 9/9/26 2020 to Present, Medicinal and Biological Chemistry, Delta Opioid Receptor Altmaniacs 9/9/26

65. Enantioselective Total Synthesis of (–)-TAN-67

Moursy, A.; Khamrai, J.; Obakpolor, O.; Altman, R. A.*

Manuscript Submitted.

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2020 to Present, Synthetic Organic Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling Altmaniacs 9/9/26 2020 to Present, Synthetic Organic Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling Altmaniacs 9/9/26

64. Palladium-Catalyzed Base-Controlled para-Selective C–H Functionalization of Arenes

Intelli, A. J.; Wayment, C. J.; Selvaraju, M.; Altman, R. A.*

Manuscript Submitted.

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2020 to Present, Medicinal and Biological Chemistry, Kynurenine Pathway Altmaniacs 9/9/26 2020 to Present, Medicinal and Biological Chemistry, Kynurenine Pathway Altmaniacs 9/9/26

63. Salicylate Protecting Group Strategies

Zhao, A.; Trombley, T. A.; Junaid, A.; Altman, R. A.*

Manuscript Submitted

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Fluorination in Medicinal Chemistry, Medicinal and Biological Chemistry, 2020 to Present Altmaniacs 2/5/26 Fluorination in Medicinal Chemistry, Medicinal and Biological Chemistry, 2020 to Present Altmaniacs 2/5/26

62. The Effect of N-Alkyl Azole Difluorination on Molecular Properties Relevant for Lead Optimization: A Comparative Study

Herrick, R. M.; Green, S. A.; Rich, S.; Grandner, J. N.; Huard, K.;* Altman, R. A.*

ACS Med. Chem. Lett. 2026, 17, 721–726.

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2020 to Present, Reviews, Medicinal and Biological Chemistry, Fluorination in Medicinal Chemistry Altmaniacs 1/26/26 2020 to Present, Reviews, Medicinal and Biological Chemistry, Fluorination in Medicinal Chemistry Altmaniacs 1/26/26

61. On the Metabolic Stability of Fluorinated Small Molecules: A Physical Organic Chemistry Perspective

Bhattarai, P. B.; Trombley, T. A.; Altman, R. A.*

J. Med. Chem. 2026, 69, 1916–1941.

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2020 to Present, Fluorinated Alkenes, Synthetic Organic Methodology, Organofluorine Methodology Altmaniacs 12/30/25 2020 to Present, Fluorinated Alkenes, Synthetic Organic Methodology, Organofluorine Methodology Altmaniacs 12/30/25

60. Selenide-Enabled Photocatalytic Hydroazolation of gem-Difluoroalkenes

Abd El Gaber M. K.; Herrick, R.; Sudhakar, P.; Rana, A.; Roach, B. A.; Dick, J. E.; Altman, R. A.*

Chem. Sci. 2025, 16, 22701–22710.

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2020 to Present, Synthetic Organic Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Organofluorine Methodology, Aromatization Altmaniacs 9/12/25 2020 to Present, Synthetic Organic Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Organofluorine Methodology, Aromatization Altmaniacs 9/12/25

59. Insights into Deoxytrifluoromethylation /Aromatization to Access Highly Substituted Trifluoromethyl Arenes

Bhattarai, P.; Abd El-Gaber, M. K.; Koley, S.K.; Altman, R. A.*

J. Org. Chem. 2025, 90, 14291–14303.

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2020 to Present, Delta Opioid Receptor, Synthetic Organic Methodology, Medicinal and Biological Chemistry Altmaniacs 8/1/25 2020 to Present, Delta Opioid Receptor, Synthetic Organic Methodology, Medicinal and Biological Chemistry Altmaniacs 8/1/25

58. Unified Enantioselective Synthesis of 5-Phenylmorphans and cis-Octahydroisoquinolines

Mahgoub, A.; Khamrai, J.; Festus, O.; Altman, R. A.*

Org. Lett. 2025, 27, 8941–8945.

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2020 to Present, Synthetic Organic Methodology Altmaniacs 8/1/25 2020 to Present, Synthetic Organic Methodology Altmaniacs 8/1/25

57. NBS-Promoted Synthesis of Maleimides by Oxidative Dearomatization of Pyrroles: Mechanistic Investigations Using Online MS in Real-Time

Kumar, A.; Mishra, P. K.; Nandy, A.; Altman, R. A.; Banerjee, S.; Verma, A. K.*

Org. Lett. 2025, 27, 7810–7815.

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2020 to Present, Medicinal and Biological Chemistry Altmaniacs 4/3/25 2020 to Present, Medicinal and Biological Chemistry Altmaniacs 4/3/25

56. Discovery of RGS2-FBXO44 interaction inhibitors using a cell-based NanoBit assay

Aryal, S.; Wong, C. S. Y.; McNabb, H. J.; Junaid, A.; Altman, R. A.; Sjögren, B.*

Mol. Pharmacol. 2025, 107, 100030.

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2020 to Present, Deoxyfluoroalkylation, Organofluorine Methodology, Synthetic Organic Methodology, Aromatization Altmaniacs 1/8/25 2020 to Present, Deoxyfluoroalkylation, Organofluorine Methodology, Synthetic Organic Methodology, Aromatization Altmaniacs 1/8/25

55. A Deoxyfluoroalkylation-Aromatization Strategy to Access Fluoroalkyl Arenes

Bhattarai, P.; Koley, S. K.; Goel, K.; Altman, R. A.*

Chem. Commun. 2025, 61, 2524–2527.

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Fluorinated Alkenes, Synthetic Organic Methodology, 2020 to Present, Organofluorine Methodology, Deoxyfluoroalkylation Altmaniacs 1/2/25 Fluorinated Alkenes, Synthetic Organic Methodology, 2020 to Present, Organofluorine Methodology, Deoxyfluoroalkylation Altmaniacs 1/2/25

54. Synthesis of 4-(2,2-Difluorovinyl)benzonitrile through a Wittig-type Olefination of 4-Formylbenzonitrile

Intelli. A. J.; Sorrentino, J. P.; Altman, R. A.*

Org. Synth. 2024, 101, 542.

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Medicinal and Biological Chemistry, 2020 to Present Altmaniacs 11/16/24 Medicinal and Biological Chemistry, 2020 to Present Altmaniacs 11/16/24

53. A Phenotypic High-Throughput Screen Identifies Small Molecule Modulators of Endogenous RGS10 in BV-2 Cells

Talele, S.; Gonzalez, S.; Trudeau, J.; Junaid, A.; Loy, C.; Altman, R. A.; Sjogren, J. B.*

J. Med. Chem. 2024, 67, 20343–20352.

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Medicinal and Biological Chemistry, Kynurenine Pathway, 2020 to Present Altmaniacs 11/2/24 Medicinal and Biological Chemistry, Kynurenine Pathway, 2020 to Present Altmaniacs 11/2/24

52. α-Amino-β-Carboxymuconate-ε-Semialdehyde Decarboxylase Catalyzes Enol/Keto Tautomerization of Oxaloacetate

Yang, Y.; Davis, I.; Altman, R. A.; Liu, A.*

J. Biol. Chem. 2024, 300, 107878.

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Organofluorine Methodology, Synthetic Organic Methodology, Fluorinated Alkenes, 2020 to Present Altmaniacs 10/1/24 Organofluorine Methodology, Synthetic Organic Methodology, Fluorinated Alkenes, 2020 to Present Altmaniacs 10/1/24

51. Palladium and Copper Co-Catalyzed Chloro-Arylation of gem-Difluorostyrenes – Use of a Nitrite Additive to Suppress β-F Elimination

Intelli, A. J.; Wayment, C. Z.; Lee, R. T.; Yuan, K.; Altman, R. A.*

Chem. Sci. 2024, 15, 17571–17578.

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Synthetic Organic Methodology, Deoxyfluoroalkylation, Aromatization, 2020 to Present, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Organofluorine Methodology Altmaniacs 8/28/24 Synthetic Organic Methodology, Deoxyfluoroalkylation, Aromatization, 2020 to Present, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Organofluorine Methodology Altmaniacs 8/28/24

50. Deoxytrifluoromethylation/Aromatization of Cyclohexan(en)ones to Access Highly Substituted Trifluoromethylarenes

Bhattarai, P.; Abd El-Gaber, M. K.; Koley, S. K.; Altman, R. A.* 

Nature Commun. 2024, 15, 7882.

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Fluorinated Alkenes, Synthetic Organic Methodology, Organofluorine Methodology, 2020 to Present Altmaniacs 6/17/24 Fluorinated Alkenes, Synthetic Organic Methodology, Organofluorine Methodology, 2020 to Present Altmaniacs 6/17/24

49. Peroxide-Initiated Hydrophosphination of gem-Difluoroalkenes

Intelli, A. J.; Lee, R. T.; Altman, R. A.*

J. Org. Chem. 2023, 88, 14012–14021.

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Synthetic Organic Methodology, Organofluorine Methodology, 2020 to Present Altmaniacs 6/17/24 Synthetic Organic Methodology, Organofluorine Methodology, 2020 to Present Altmaniacs 6/17/24

48. Palladium-Catalyzed Dearomatization of Benzothiophenes: Isolation and Functionalization of a Discrete Dearomatized Intermediate

Intelli, A. J.; Pal, M.; Selvaraju, M.; Altman, R. A.*

Synthesis 2023, 55, 3568–3574.

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Fluorinated Alkenes, Organofluorine Methodology, Synthetic Organic Methodology, 2020 to Present Altmaniacs 6/17/24 Fluorinated Alkenes, Organofluorine Methodology, Synthetic Organic Methodology, 2020 to Present Altmaniacs 6/17/24

47. A Diselenide Additive Enables Photocatalytic Hydroalkoxylation of gem-Difluoroalkenes

Herrick, R. M.; Abd El-Gaber, M. K.; Rodriguez, L. G. C.; Altman, R. A.*

Chem. Commun. 2023, 59, 5623–5626.

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