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Synthetic Fluorination Methodology
Medicinal and Biological Chemistry
All Publications
Synthetic Organic Methodology
Medicinal and Biological Chemistry
Reviews
Graduate and Postdoctoral Work
Book Chapters and Minor Works
Ryan Altman
Our Team
Links
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Synthetic Fluorination Methodology
Medicinal and Biological Chemistry
Folder: Publications
Back
All Publications
Synthetic Organic Methodology
Medicinal and Biological Chemistry
Reviews
Graduate and Postdoctoral Work
Book Chapters and Minor Works
Ryan Altman
Our Team
Links
2020 to Present, Synthetic Organic Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling Altmaniacs 9/9/26 2020 to Present, Synthetic Organic Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling Altmaniacs 9/9/26

64. Palladium-Catalyzed Base-Controlled para-Selective C–H Functionalization of Arenes

Intelli, A. J.; Wayment, C. J.; Selvaraju, M.; Altman, R. A.*

Manuscript Submitted.

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2020 to Present, Synthetic Organic Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Organofluorine Methodology, Aromatization Altmaniacs 9/12/25 2020 to Present, Synthetic Organic Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Organofluorine Methodology, Aromatization Altmaniacs 9/12/25

59. Insights into Deoxytrifluoromethylation /Aromatization to Access Highly Substituted Trifluoromethyl Arenes

Bhattarai, P.; Abd El-Gaber, M. K.; Koley, S.K.; Altman, R. A.*

J. Org. Chem. 2025, 90, 14291–14303.

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Synthetic Organic Methodology, Deoxyfluoroalkylation, Aromatization, 2020 to Present, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Organofluorine Methodology Altmaniacs 8/28/24 Synthetic Organic Methodology, Deoxyfluoroalkylation, Aromatization, 2020 to Present, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Organofluorine Methodology Altmaniacs 8/28/24

50. Deoxytrifluoromethylation/Aromatization of Cyclohexan(en)ones to Access Highly Substituted Trifluoromethylarenes

Bhattarai, P.; Abd El-Gaber, M. K.; Koley, S. K.; Altman, R. A.* 

Nature Commun. 2024, 15, 7882.

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Decarboxylative and Deoxygenative Fluoroalkylation Coupling, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24 Decarboxylative and Deoxygenative Fluoroalkylation Coupling, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24

35. Connecting Remote C–H Bond Functionalization and Decarboxylative Coupling Using Simple Amines

de Azambuja, F.; Yang, M.-H.; Feoktistova, T.; Selvaraju, M.; Brueckner, A. C.; Grove, M. A.; Koley, S.; Cheong, P. H.-Y.;* Altman, R. A.*

Nature Chem. 2020, 12, 489–496.

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Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24 Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24

33. BBDFA: A Practical Reagent for Trifluoromethylation of Allylic and Benzylic Alcohols on Preparative Scale

Han, C.;* Alabanza, L. M.; Kelly, S. M.; Orsi, D. L.; Gosselin, F.; Altman, R. A.*

Org. Proc. Res. Dev. 2019, 23, 1695–1702.

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Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24 Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24

30. Catalytic One-Step Deoxytrifluoromethylation of Alcohols

de Azambuja, F.; Lovrien, S. K.; Ross, P.; Ambler, B. R.; Altman, R. A.*

J. Org. Chem. 2019, 84, 2061–2071.

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Reviews, Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology Altmaniacs 6/14/24 Reviews, Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology Altmaniacs 6/14/24

23. Metal-catalyzed Decarboxylative Fluoroalkylation Reactions

Ambler, B. R.; Yang, M.-H.; Altman, R. A.*

Synlett 2016, 27, 2747–2755.

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Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24 Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24

22. Palladium Catalysis Enables Benzylation of α,α-Difluoroketone Enolates

Yang, M.-H.; Hunt, J. R.; Sharifi, N.; Altman, R. A.*

Angew. Chem. Int. Ed. 2016, 55, 9080–9083.

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Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24 Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24

21. Copper-Catalyzed Synthesis of Trifluoroethylarenes from Benzylic Bromodifluoroacetates

Ambler, B. R.; Zhu, L.; Altman, R. A.*

J. Org. Chem. 2015, 80, 8449–8457.

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Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24 Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24

20. Ligand-controlled Regioselective Cu-Catalyzed Trifluoromethylation to Generate Trifluoromethyl Allenes

Ambler, B. R.; Peddi, S.; Altman, R. A.*

Org. Lett. 2015, 17, 2506–2509.

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Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24 Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24

19. Ligand-Controlled Regiodivergent Palladium-catalyzed Decarboxylative Allylation Reaction to Access α,α-Difluoroketones

Yang, M.-H.; Orsi, D.; Altman, R. A.*

Angew. Chem. Int. Ed. 2015, 54, 2361–2365.

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Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020, Fluorinated Alkenes Altmaniacs 6/14/24 Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020, Fluorinated Alkenes Altmaniacs 6/14/24

18. Metal-free Trifluoromethylation of Aromatic and Heteroaromatic Aldehydes and Ketones

Qiao, Y.; Si, T.; Yang, M.-H.; Altman, R. A.*

J. Org. Chem. 2014, 79, 7122–7131.

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Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24 Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24

17. Copper-catalyzed Conversion of Propargylic Bromodifluoroacetates to Trifluoromethanes

Ambler, B. R.; Peddi, S.; Altman, R. A.*

Synthesis 2014, 46, 1938–1946.

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Reviews, Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24 Reviews, Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24

16. Decarboxylative Fluorination Strategies for Accessing Medicinally-Relevant Products

Qiao, Y.; Ambler, B. R.; Zhu, L.; Altman, R. A.*

Curr. Top. Med. Chem. 2014, 14, 966–978.

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Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24 Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24

15. Copper-Catalyzed Trifluoromethylation of Allylic Bromodifluoroacetic Esters

Ambler, B. R.; Altman, R. A.*

Org. Lett. 2013, 15, 5578–5581.

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Organofluorine Methodology, Synthetic Organic Methodology, Pre 2020, Deoxyfluoroalkylation, Decarboxylative and Deoxygenative Fluoroalkylation Coupling Altmaniacs 6/14/24 Organofluorine Methodology, Synthetic Organic Methodology, Pre 2020, Deoxyfluoroalkylation, Decarboxylative and Deoxygenative Fluoroalkylation Coupling Altmaniacs 6/14/24

14. Copper-Mediated Deoxygenative Trifluoromethylation of Benzylic Xanthates: Formation of C(sp3)–CF3 from an O-Based Electrophile

Zhu, L.; Liu, S.; Douglas, J. T.; Altman, R. A.*

Chem. Eur. J. 2013, 19, 12800–12805.

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