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Synthetic Fluorination Methodology
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Medicinal and Biological Chemistry
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Graduate and Postdoctoral Work
Book Chapters and Minor Works
Ryan Altman
Our Team
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Synthetic Fluorination Methodology
Medicinal and Biological Chemistry
Folder: Publications
Back
All Publications
Synthetic Organic Methodology
Medicinal and Biological Chemistry
Reviews
Graduate and Postdoctoral Work
Book Chapters and Minor Works
Ryan Altman
Our Team
Links
2020 to Present, Fluorinated Alkenes, Synthetic Organic Methodology, Organofluorine Methodology Altmaniacs 12/30/25 2020 to Present, Fluorinated Alkenes, Synthetic Organic Methodology, Organofluorine Methodology Altmaniacs 12/30/25

60. Selenide-Enabled Photocatalytic Hydroazolation of gem-Difluoroalkenes

Abd El Gaber M. K.; Herrick, R.; Sudhakar, P.; Rana, A.; Roach, B. A.; Dick, J. E.; Altman, R. A.*

Chem. Sci. 2025, 16, 22701–22710.

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2020 to Present, Synthetic Organic Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Organofluorine Methodology, Aromatization Altmaniacs 9/12/25 2020 to Present, Synthetic Organic Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Organofluorine Methodology, Aromatization Altmaniacs 9/12/25

59. Insights into Deoxytrifluoromethylation /Aromatization to Access Highly Substituted Trifluoromethyl Arenes

Bhattarai, P.; Abd El-Gaber, M. K.; Koley, S.K.; Altman, R. A.*

J. Org. Chem. 2025, 90, 14291–14303.

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2020 to Present, Deoxyfluoroalkylation, Organofluorine Methodology, Synthetic Organic Methodology, Aromatization Altmaniacs 1/8/25 2020 to Present, Deoxyfluoroalkylation, Organofluorine Methodology, Synthetic Organic Methodology, Aromatization Altmaniacs 1/8/25

55. A Deoxyfluoroalkylation-Aromatization Strategy to Access Fluoroalkyl Arenes

Bhattarai, P.; Koley, S. K.; Goel, K.; Altman, R. A.*

Chem. Commun. 2025, 61, 2524–2527.

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Fluorinated Alkenes, Synthetic Organic Methodology, 2020 to Present, Organofluorine Methodology, Deoxyfluoroalkylation Altmaniacs 1/2/25 Fluorinated Alkenes, Synthetic Organic Methodology, 2020 to Present, Organofluorine Methodology, Deoxyfluoroalkylation Altmaniacs 1/2/25

54. Synthesis of 4-(2,2-Difluorovinyl)benzonitrile through a Wittig-type Olefination of 4-Formylbenzonitrile

Intelli. A. J.; Sorrentino, J. P.; Altman, R. A.*

Org. Synth. 2024, 101, 542.

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Organofluorine Methodology, Synthetic Organic Methodology, Fluorinated Alkenes, 2020 to Present Altmaniacs 10/1/24 Organofluorine Methodology, Synthetic Organic Methodology, Fluorinated Alkenes, 2020 to Present Altmaniacs 10/1/24

51. Palladium and Copper Co-Catalyzed Chloro-Arylation of gem-Difluorostyrenes – Use of a Nitrite Additive to Suppress β-F Elimination

Intelli, A. J.; Wayment, C. Z.; Lee, R. T.; Yuan, K.; Altman, R. A.*

Chem. Sci. 2024, 15, 17571–17578.

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Synthetic Organic Methodology, Deoxyfluoroalkylation, Aromatization, 2020 to Present, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Organofluorine Methodology Altmaniacs 8/28/24 Synthetic Organic Methodology, Deoxyfluoroalkylation, Aromatization, 2020 to Present, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Organofluorine Methodology Altmaniacs 8/28/24

50. Deoxytrifluoromethylation/Aromatization of Cyclohexan(en)ones to Access Highly Substituted Trifluoromethylarenes

Bhattarai, P.; Abd El-Gaber, M. K.; Koley, S. K.; Altman, R. A.* 

Nature Commun. 2024, 15, 7882.

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Fluorinated Alkenes, Synthetic Organic Methodology, Organofluorine Methodology, 2020 to Present Altmaniacs 6/17/24 Fluorinated Alkenes, Synthetic Organic Methodology, Organofluorine Methodology, 2020 to Present Altmaniacs 6/17/24

49. Peroxide-Initiated Hydrophosphination of gem-Difluoroalkenes

Intelli, A. J.; Lee, R. T.; Altman, R. A.*

J. Org. Chem. 2023, 88, 14012–14021.

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Synthetic Organic Methodology, Organofluorine Methodology, 2020 to Present Altmaniacs 6/17/24 Synthetic Organic Methodology, Organofluorine Methodology, 2020 to Present Altmaniacs 6/17/24

48. Palladium-Catalyzed Dearomatization of Benzothiophenes: Isolation and Functionalization of a Discrete Dearomatized Intermediate

Intelli, A. J.; Pal, M.; Selvaraju, M.; Altman, R. A.*

Synthesis 2023, 55, 3568–3574.

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Fluorinated Alkenes, Organofluorine Methodology, Synthetic Organic Methodology, 2020 to Present Altmaniacs 6/17/24 Fluorinated Alkenes, Organofluorine Methodology, Synthetic Organic Methodology, 2020 to Present Altmaniacs 6/17/24

47. A Diselenide Additive Enables Photocatalytic Hydroalkoxylation of gem-Difluoroalkenes

Herrick, R. M.; Abd El-Gaber, M. K.; Rodriguez, L. G. C.; Altman, R. A.*

Chem. Commun. 2023, 59, 5623–5626.

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Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/17/24 Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/17/24

46. Photocatalytic Hydrothiolation of gem-Difluoroalkenes

Sorrentino, J. P.; Herrick, R. M.; Abd El-Gaber, M. K.; Abdelazem, A. Z.; Altman, R. A.*

J. Org. Chem. 2022, 87, 16676–16690.

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Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/17/24 Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/17/24

45. Cu(II)-Catalyzed Oxidation of gem-Difluoroalkenes Generate α,α-Difluorinated-α-Phenoxyketones

Koley, S.; Cayton, K. T.; González-Montiel, G. A.; Yadav, M. R.; Orsi, D. L.; Intelli, A. J.; Cheong, P. H.-Y.;* Altman, R. A.*

J. Org. Chem. 2022, 87, 10710–10725.

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Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology, Reviews Altmaniacs 6/17/24 Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology, Reviews Altmaniacs 6/17/24

42. Fluorine-Retentive Strategies for the Functionalization of gem-Difluoroalkenes

Sorrentino, J. P.; Altman, R. A.*

Synthesis 2021, 53, 3935–3950.

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Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24 Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24

41. Acid-catalyzed Hydrothiolation of gem-Difluorostyrenes to Access α,α-Difluoroalkylthioethers

Sorrentino, J. P.; Orsi, D. L.; Altman, R. A.*

J. Org. Chem. 2021, 86, 2297–2311.

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Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24 Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24

39. Arylation of gem-difluoroalkenes using a Pd/Cu Co-catalytic system that avoids β-fluoride elimination

Yuan, K.; Feoktistova, T.; Cheong, P. H.-Y.;* Altman, R. A.*

Chem. Sci. 2021, 12, 1363–1367.

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Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24 Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24

38. Cobalt-Catalyzed Selective Unsymmetric Dioxidation of β,β-Difluorostyrenes

Orsi, D. L.; Sorrentino, J. P.; Douglas, J. T.; Altman, R. A.*

J. Org. Chem. 2020, 85, 10451–10465.

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Fluorinated Alkenes, Reviews, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24 Fluorinated Alkenes, Reviews, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24

36. Recent Advances in Transition Metal Catalyzed Functionalization of gem-Difluoroalkenes

Koley, S.; Altman, R. A.*

Isr. J. Chem. 2020, 60, 313–339.

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Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24 Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24

33. BBDFA: A Practical Reagent for Trifluoromethylation of Allylic and Benzylic Alcohols on Preparative Scale

Han, C.;* Alabanza, L. M.; Kelly, S. M.; Orsi, D. L.; Gosselin, F.; Altman, R. A.*

Org. Proc. Res. Dev. 2019, 23, 1695–1702.

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Fluorinated Alkenes, Organofluorine Methodology, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24 Fluorinated Alkenes, Organofluorine Methodology, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24

32. Organocatalytic Strategy for Hydrophenolation of gem-Difluoroalkenes

Orsi, D. L.; Yadav, M. R.; Altman, R. A.*

Tetrahedron 2019, 75, 4325–4336.

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Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24 Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24

30. Catalytic One-Step Deoxytrifluoromethylation of Alcohols

de Azambuja, F.; Lovrien, S. K.; Ross, P.; Ambler, B. R.; Altman, R. A.*

J. Org. Chem. 2019, 84, 2061–2071.

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Reviews, Organofluorine Methodology, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24 Reviews, Organofluorine Methodology, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24

26. Exploiting the Unusual Effects of Fluorine in Methodology

Orsi, D. L.; Altman, R. A.*

Chem. Commun. 2017, 53, 7168–7181.

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