Publications

2020 — Present

Featured

66. Deoxytrifluoromethylation/Aromatization to Access Highly Substituted Fluoroalkyl Arenes Under Milder Aromatization Conditions

Bhattarai, P. B.; Zhao, A. Y.; Wise, J. W.; Cowper, N. G. W.; Gilbert, M. M.; Morrill, W. H.; Tao, D. J.; Goel K.; Altman, R. A.*

Manuscript Submitted.

65. Enantioselective Total Synthesis of (–)-TAN-67

Moursy, A.; Khamrai, J.; Obakpolor, O.; Altman, R. A.*

Manuscript Submitted.

64. Palladium-Catalyzed Base-Controlled para-Selective C–H Functionalization of Arenes

Intelli, A. J.; Wayment, C. J.; Selvaraju, M.; Altman, R. A.*

Manuscript Submitted.

63. Salicylate Protecting Group Strategies

Zhao, A.; Trombley, T. A.; Junaid, A.; Altman, R. A.*

Manuscript Submitted

62. The Effect of N-Alkyl Azole Difluorination on Molecular Properties Relevant for Lead Optimization: A Comparative Study

Herrick, R. M.; Green, S. A.; Rich, S.; Grandner, J. N.; Huard, K.;* Altman, R. A.*

ACS Med. Chem. Lett. 2026, 17, 721–726.

61. On the Metabolic Stability of Fluorinated Small Molecules: A Physical Organic Chemistry Perspective

Bhattarai, P. B.; Trombley, T. A.; Altman, R. A.*

J. Med. Chem. 2026, 69, 1916–1941.

60. Selenide-Enabled Photocatalytic Hydroazolation of gem-Difluoroalkenes

Abd El Gaber M. K.; Herrick, R.; Sudhakar, P.; Rana, A.; Roach, B. A.; Dick, J. E.; Altman, R. A.*

Chem. Sci. 2025, 16, 22701–22710.

59. Insights into Deoxytrifluoromethylation /Aromatization to Access Highly Substituted Trifluoromethyl Arenes

Bhattarai, P.; Abd El-Gaber, M. K.; Koley, S.K.; Altman, R. A.*

J. Org. Chem. 2025, 90, 14291–14303.

58. Unified Enantioselective Synthesis of 5-Phenylmorphans and cis-Octahydroisoquinolines

Mahgoub, A.; Khamrai, J.; Festus, O.; Altman, R. A.*

Org. Lett. 2025, 27, 8941–8945.

57. NBS-Promoted Synthesis of Maleimides by Oxidative Dearomatization of Pyrroles: Mechanistic Investigations Using Online MS in Real-Time

Kumar, A.; Mishra, P. K.; Nandy, A.; Altman, R. A.; Banerjee, S.; Verma, A. K.*

Org. Lett. 2025, 27, 7810–7815.

56. Discovery of RGS2-FBXO44 interaction inhibitors using a cell-based NanoBit assay

Aryal, S.; Wong, C. S. Y.; McNabb, H. J.; Junaid, A.; Altman, R. A.; Sjögren, B.*

Mol. Pharmacol. 2025, 107, 100030.

55. A Deoxyfluoroalkylation-Aromatization Strategy to Access Fluoroalkyl Arenes

Bhattarai, P.; Koley, S. K.; Goel, K.; Altman, R. A.*

Chem. Commun. 2025, 61, 2524–2527.

54. Synthesis of 4-(2,2-Difluorovinyl)benzonitrile through a Wittig-type Olefination of 4-Formylbenzonitrile

Intelli. A. J.; Sorrentino, J. P.; Altman, R. A.*

Org. Synth. 2024, 101, 542.

53. A Phenotypic High-Throughput Screen Identifies Small Molecule Modulators of Endogenous RGS10 in BV-2 Cells

Talele, S.; Gonzalez, S.; Trudeau, J.; Junaid, A.; Loy, C.; Altman, R. A.; Sjogren, J. B.*

J. Med. Chem. 2024, 67, 20343–20352.

52. α-Amino-β-Carboxymuconate-ε-Semialdehyde Decarboxylase Catalyzes Enol/Keto Tautomerization of Oxaloacetate

Yang, Y.; Davis, I.; Altman, R. A.; Liu, A.*

J. Biol. Chem. 2024, 300, 107878.

51. Palladium and Copper Co-Catalyzed Chloro-Arylation of gem-Difluorostyrenes – Use of a Nitrite Additive to Suppress β-F Elimination

Intelli, A. J.; Wayment, C. Z.; Lee, R. T.; Yuan, K.; Altman, R. A.*

Chem. Sci. 2024, 15, 17571–17578.

50. Deoxytrifluoromethylation/Aromatization of Cyclohexan(en)ones to Access Highly Substituted Trifluoromethylarenes

Bhattarai, P.; Abd El-Gaber, M. K.; Koley, S. K.; Altman, R. A.*

Nature Commun. 2024, 15, 7882.

49. Peroxide-Initiated Hydrophosphination of gem-Difluoroalkenes

Intelli, A. J.; Lee, R. T.; Altman, R. A.*

J. Org. Chem. 2023, 88, 14012–14021.

48. Palladium-Catalyzed Dearomatization of Benzothiophenes: Isolation and Functionalization of a Discrete Dearomatized Intermediate

Intelli, A. J.; Pal, M.; Selvaraju, M.; Altman, R. A.*

Synthesis 2023, 55, 3568–3574.

47. A Diselenide Additive Enables Photocatalytic Hydroalkoxylation of gem-Difluoroalkenes

Herrick, R. M.; Abd El-Gaber, M. K.; Rodriguez, L. G. C.; Altman, R. A.*

Chem. Commun. 2023, 59, 5623–5626.

46. Photocatalytic Hydrothiolation of gem-Difluoroalkenes

Sorrentino, J. P.; Herrick, R. M.; Abd El-Gaber, M. K.; Abdelazem, A. Z.; Altman, R. A.*

J. Org. Chem. 2022, 87, 16676–16690.

45. Cu(II)-Catalyzed Oxidation of gem-Difluoroalkenes Generate α,α-Difluorinated-α-Phenoxyketones

Koley, S.; Cayton, K. T.; González-Montiel, G. A.; Yadav, M. R.; Orsi, D. L.; Intelli, A. J.; Cheong, P. H.-Y.;* Altman, R. A.*

J. Org. Chem. 2022, 87, 10710–10725.

44. Fluoroalkylation of Dextromethorphan Improves CNS Exposure and Metabolic Stability

Sorrentino, J. P.; Altman, R. A.*

ACS Med. Chem. Lett. 2022, 13, 707–713.

43. Modulating β-Arrestin-2 Recruitment at the δ- and μ-Opioid Receptors

Sharma K. S.; Cassell, R. J.; Meqbil, Y. J.; Su, H.; Blaine, A. T.; Cummins, B. R.; Mores, K. L.; Johnson, D.; van Rijn, R. M.;* Altman, R. A.*

RSC Med. Chem. 2021, 12, 1958–1967.

42. Fluorine-Retentive Strategies for the Functionalization of gem-Difluoroalkenes

Sorrentino, J. P.; Altman, R. A.*

Synthesis 2021, 53, 3935–3950.

41. Acid-catalyzed Hydrothiolation of gem-Difluorostyrenes to Access α,α-Difluoroalkylthioethers

Sorrentino, J. P.; Orsi, D. L.; Altman, R. A.*

J. Org. Chem. 2021, 86, 2297–2311.

40. Diflunisal Derivatives as Modulators of ACMS Decarboxylase Targeting the Tryptophan-Kynurenine Pathway

Yang, Y.; Borel, T.; de Azambuja, F.; Johnson, D.; Sorrentino, J. P.; Udokwu, C.; Davis, I.; Liu, A.;* Altman, R. A.*

J. Med. Chem. 2021, 64, 797–811.

39. Arylation of gem-difluoroalkenes using a Pd/Cu Co-catalytic system that avoids β-fluoride elimination

Yuan, K.; Feoktistova, T.; Cheong, P. H.-Y.;* Altman, R. A.*

Chem. Sci. 2021, 12, 1363–1367.

38. Cobalt-Catalyzed Selective Unsymmetric Dioxidation of β,β-Difluorostyrenes

Orsi, D. L.; Sorrentino, J. P.; Douglas, J. T.; Altman, R. A.*

J. Org. Chem. 2020, 85, 10451–10465.

37. Late-Stage Conversion of a Metabolically Labile Aryl Methyl Ether-Containing Natural Product to Fluoroalkyl Analogues

Sorrentino, J. S.; Ambler, B. R.; Altman, R. A.*

J. Org. Chem. 2020, 85, 5416–5427.

Featured

34. The Meta-Position of Phe4 in Leu-enkephalin Regulates Potency, Selectivity, Functional Activity, and Signaling Bias at the Delta and Mu Opioid Receptors

Cassell, R. J.; Sharma K. S.; Su, H.; Cummins, B. R.; Cui, H.; Mores, K. L.; Blaine, A. T.; Altman, R. A.;* van Rijn, R. M.*

Molecules 2019, 24, 4542.

33. BBDFA: A Practical Reagent for Trifluoromethylation of Allylic and Benzylic Alcohols on Preparative Scale

Han, C.;* Alabanza, L. M.; Kelly, S. M.; Orsi, D. L.; Gosselin, F.; Altman, R. A.*

Org. Proc. Res. Dev. 2019, 23, 1695–1702.

32. Organocatalytic Strategy for Hydrophenolation of gem-Difluoroalkenes

Orsi, D. L.; Yadav, M. R.; Altman, R. A.*

Tetrahedron 2019, 75, 4325–4336.

31. Synthesis of C2-Deutero-L-Tryptophan by Sequential Ir-Catalyzed Reactions

Vallakati, R. K.; Plotnikov, A. T.; Altman, R. A.*

Tetrahedron 2019, 75, 2261–2264.

30. Catalytic One-Step Deoxytrifluoromethylation of Alcohols

de Azambuja, F.; Lovrien, S. K.; Ross, P.; Ambler, B. R.; Altman, R. A.*

J. Org. Chem. 2019, 84, 2061–2071.

29. Synthesis of Leu-Enkephalin Peptidomimetics Containing Trifluromethylalkenes as Amide Isopolar Mimics

Eeda, V.; Selvaraju, M.; Altman, R. A.*

J. Fluorine Chem. 2019, 218, 90–98.

28. Tyr1-ψ[(Z)CF═CH]-Gly2 Fluorinated Peptidomimetic Improves Distribution and Metabolism Properties of Leu-Enkephalin

Altman, R. A.*; Sharma, K. K.; Rajewski, L. G.; Toren, P. C.; Baltezor, M. J.; Pal, M.; Karad, S. N.

ACS Chem. Neurosci. 2018, 9, 1735–1742.

27. Stepwise O-Atom Transfer in Heme-based Tryptophan Dioxygenase: The Role of Substrate Ammonium in the Epoxide Ring Opening

Shin, I.; Ambler, B. R.; Wherritt, D.; Griffith, W.; Maldonado, A.; Altman, R. A.;* Liu, A.*

J. Am. Chem. Soc. 2018, 140, 4372–4379.

26. Exploiting the Unusual Effects of Fluorine in Methodology

Orsi, D. L.; Altman, R. A.*

Chem. Commun. 2017, 53, 7168–7181.

25. Base Catalysis Enables Access to α,α-Difluoroalkylthio-ethers

Orsi, D. L.; Easley, B. J.; Lick, A. M.; Altman, R. A.*

Org. Lett. 2017, 19, 1570–1573.

24. Synthesis and Opioid Activity of Tyr1–ψ[(Z)CF=CH]–Gly2 and Tyr1–ψ[(S)/(R)-CF3CH–NH]–Gly2 Leu-enkephalin Fluorinated Peptidomimetics

Karad, S. N.; Pal, M.; Crowley, R. S.; Prisinzano, T. E.; Altman, R. A.*

ChemMedChem 2017, 12, 571–576.

22. Palladium Catalysis Enables Benzylation of α,α-Difluoroketone Enolates

Yang, M.-H.; Hunt, J. R.; Sharifi, N.; Altman, R. A.*

Angew. Chem. Int. Ed. 2016, 55, 9080–9083.

21. Copper-Catalyzed Synthesis of Trifluoroethylarenes from Benzylic Bromodifluoroacetates

Ambler, B. R.; Zhu, L.; Altman, R. A.*

J. Org. Chem. 2015, 80, 8449–8457.

20. Ligand-controlled Regioselective Cu-Catalyzed Trifluoromethylation to Generate Trifluoromethyl Allenes

Ambler, B. R.; Peddi, S.; Altman, R. A.*

Org. Lett. 2015, 17, 2506–2509.

19. Ligand-Controlled Regiodivergent Palladium-catalyzed Decarboxylative Allylation Reaction to Access α,α-Difluoroketones

Yang, M.-H.; Orsi, D.; Altman, R. A.*

Angew. Chem. Int. Ed. 2015, 54, 2361–2365.

18. Metal-free Trifluoromethylation of Aromatic and Heteroaromatic Aldehydes and Ketones

Qiao, Y.; Si, T.; Yang, M.-H.; Altman, R. A.*

J. Org. Chem. 2014, 79, 7122–7131.

17. Copper-catalyzed Conversion of Propargylic Bromodifluoroacetates to Trifluoromethanes

Ambler, B. R.; Peddi, S.; Altman, R. A.*

Synthesis 2014, 46, 1938–1946.

16. Decarboxylative Fluorination Strategies for Accessing Medicinally-Relevant Products

Qiao, Y.; Ambler, B. R.; Zhu, L.; Altman, R. A.*

Curr. Top. Med. Chem. 2014, 14, 966–978.

15. Copper-Catalyzed Trifluoromethylation of Allylic Bromodifluoroacetic Esters

Ambler, B. R.; Altman, R. A.*

Org. Lett. 2013, 15, 5578–5581.

14. Copper-Mediated Deoxygenative Trifluoromethylation of Benzylic Xanthates: Formation of C(sp3)–CF3 from an O-Based Electrophile

Zhu, L.; Liu, S.; Douglas, J. T.; Altman, R. A.*

Chem. Eur. J. 2013, 19, 12800–12805.

13. Preparation of Fluoroalkenes via the Shapiro Reaction: Direct Access to Fluorinated Peptidomimetics

Yang, M. H.; Matikonda, S. S.; Altman, R. A.*

Org. Lett. 2013, 15, 3894–3897.

Reviews

Graduate and Postdoctoral Work

Book Chapters and Minor Works

Before 2020

Synthetic Organic Chemistry

Medicinal and Biological Chemistry

Reviews

Graduate and Postdoctoral Work

Book Chapters and Minor Works

Publications

2020 — Present

Before 2020

Altman Lab