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Synthetic Fluorination Methodology
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Synthetic Fluorination Methodology
Medicinal and Biological Chemistry
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All Publications
Synthetic Organic Methodology
Medicinal and Biological Chemistry
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Graduate and Postdoctoral Work
Book Chapters and Minor Works
Ryan Altman
Our Team
Links
Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/17/24 Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/17/24

46. Photocatalytic Hydrothiolation of gem-Difluoroalkenes

Sorrentino, J. P.; Herrick, R. M.; Abd El-Gaber, M. K.; Abdelazem, A. Z.; Altman, R. A.*

J. Org. Chem. 2022, 87, 16676–16690.

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Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/17/24 Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/17/24

45. Cu(II)-Catalyzed Oxidation of gem-Difluoroalkenes Generate α,α-Difluorinated-α-Phenoxyketones

Koley, S.; Cayton, K. T.; González-Montiel, G. A.; Yadav, M. R.; Orsi, D. L.; Intelli, A. J.; Cheong, P. H.-Y.;* Altman, R. A.*

J. Org. Chem. 2022, 87, 10710–10725.

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Fluorination in Medicinal Chemistry, Medicinal and Biological Chemistry, 2020 to Present Altmaniacs 6/17/24 Fluorination in Medicinal Chemistry, Medicinal and Biological Chemistry, 2020 to Present Altmaniacs 6/17/24

44. Fluoroalkylation of Dextromethorphan Improves CNS Exposure and Metabolic Stability

Sorrentino, J. P.; Altman, R. A.*

ACS Med. Chem. Lett. 2022, 13, 707–713.

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Delta Opioid Receptor, Fluorination in Medicinal Chemistry, Medicinal and Biological Chemistry, 2020 to Present Altmaniacs 6/17/24 Delta Opioid Receptor, Fluorination in Medicinal Chemistry, Medicinal and Biological Chemistry, 2020 to Present Altmaniacs 6/17/24

43. Modulating β-Arrestin-2 Recruitment at the δ- and μ-Opioid Receptors

Sharma K. S.; Cassell, R. J.; Meqbil, Y. J.; Su, H.; Blaine, A. T.; Cummins, B. R.; Mores, K. L.; Johnson, D.; van Rijn, R. M.;* Altman, R. A.*

RSC Med. Chem. 2021, 12, 1958–1967.

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Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology, Reviews Altmaniacs 6/17/24 Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology, Reviews Altmaniacs 6/17/24

42. Fluorine-Retentive Strategies for the Functionalization of gem-Difluoroalkenes

Sorrentino, J. P.; Altman, R. A.*

Synthesis 2021, 53, 3935–3950.

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Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24 Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24

41. Acid-catalyzed Hydrothiolation of gem-Difluorostyrenes to Access α,α-Difluoroalkylthioethers

Sorrentino, J. P.; Orsi, D. L.; Altman, R. A.*

J. Org. Chem. 2021, 86, 2297–2311.

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Kynurenine Pathway, Medicinal and Biological Chemistry, 2020 to Present Altmaniacs 6/14/24 Kynurenine Pathway, Medicinal and Biological Chemistry, 2020 to Present Altmaniacs 6/14/24

40. Diflunisal Derivatives as Modulators of ACMS Decarboxylase Targeting the Tryptophan-Kynurenine Pathway

Yang, Y.; Borel, T.; de Azambuja, F.; Johnson, D.; Sorrentino, J. P.; Udokwu, C.; Davis, I.; Liu, A.;* Altman, R. A.*

J. Med. Chem. 2021, 64, 797–811.

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Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24 Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24

39. Arylation of gem-difluoroalkenes using a Pd/Cu Co-catalytic system that avoids β-fluoride elimination

Yuan, K.; Feoktistova, T.; Cheong, P. H.-Y.;* Altman, R. A.*

Chem. Sci. 2021, 12, 1363–1367.

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Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24 Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24

38. Cobalt-Catalyzed Selective Unsymmetric Dioxidation of β,β-Difluorostyrenes

Orsi, D. L.; Sorrentino, J. P.; Douglas, J. T.; Altman, R. A.*

J. Org. Chem. 2020, 85, 10451–10465.

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Fluorination in Medicinal Chemistry, Medicinal and Biological Chemistry, 2020 to Present Altmaniacs 6/14/24 Fluorination in Medicinal Chemistry, Medicinal and Biological Chemistry, 2020 to Present Altmaniacs 6/14/24

37. Late-Stage Conversion of a Metabolically Labile Aryl Methyl Ether-Containing Natural Product to Fluoroalkyl Analogues

Sorrentino, J. S.; Ambler, B. R.; Altman, R. A.*

J. Org. Chem. 2020, 85, 5416–5427.

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Fluorinated Alkenes, Reviews, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24 Fluorinated Alkenes, Reviews, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24

36. Recent Advances in Transition Metal Catalyzed Functionalization of gem-Difluoroalkenes

Koley, S.; Altman, R. A.*

Isr. J. Chem. 2020, 60, 313–339.

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Decarboxylative and Deoxygenative Fluoroalkylation Coupling, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24 Decarboxylative and Deoxygenative Fluoroalkylation Coupling, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24

35. Connecting Remote C–H Bond Functionalization and Decarboxylative Coupling Using Simple Amines

de Azambuja, F.; Yang, M.-H.; Feoktistova, T.; Selvaraju, M.; Brueckner, A. C.; Grove, M. A.; Koley, S.; Cheong, P. H.-Y.;* Altman, R. A.*

Nature Chem. 2020, 12, 489–496.

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Delta Opioid Receptor, Medicinal and Biological Chemistry, Pre 2020 Altmaniacs 6/14/24 Delta Opioid Receptor, Medicinal and Biological Chemistry, Pre 2020 Altmaniacs 6/14/24

34. The Meta-Position of Phe4 in Leu-enkephalin Regulates Potency, Selectivity, Functional Activity, and Signaling Bias at the Delta and Mu Opioid Receptors

Cassell, R. J.; Sharma K. S.; Su, H.; Cummins, B. R.; Cui, H.; Mores, K. L.; Blaine, A. T.; Altman, R. A.;* van Rijn, R. M.*

Molecules 2019, 24, 4542.

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Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24 Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24

33. BBDFA: A Practical Reagent for Trifluoromethylation of Allylic and Benzylic Alcohols on Preparative Scale

Han, C.;* Alabanza, L. M.; Kelly, S. M.; Orsi, D. L.; Gosselin, F.; Altman, R. A.*

Org. Proc. Res. Dev. 2019, 23, 1695–1702.

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Fluorinated Alkenes, Organofluorine Methodology, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24 Fluorinated Alkenes, Organofluorine Methodology, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24

32. Organocatalytic Strategy for Hydrophenolation of gem-Difluoroalkenes

Orsi, D. L.; Yadav, M. R.; Altman, R. A.*

Tetrahedron 2019, 75, 4325–4336.

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Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24 Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24

31. Synthesis of C2-Deutero-L-Tryptophan by Sequential Ir-Catalyzed Reactions

Vallakati, R. K.; Plotnikov, A. T.; Altman, R. A.*

Tetrahedron 2019, 75, 2261–2264.

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Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24 Organofluorine Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Synthetic Organic Methodology, Pre 2020 Altmaniacs 6/14/24

30. Catalytic One-Step Deoxytrifluoromethylation of Alcohols

de Azambuja, F.; Lovrien, S. K.; Ross, P.; Ambler, B. R.; Altman, R. A.*

J. Org. Chem. 2019, 84, 2061–2071.

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Fluorination in Medicinal Chemistry, Medicinal and Biological Chemistry, Pre 2020 Altmaniacs 6/14/24 Fluorination in Medicinal Chemistry, Medicinal and Biological Chemistry, Pre 2020 Altmaniacs 6/14/24

29. Synthesis of Leu-Enkephalin Peptidomimetics Containing Trifluromethylalkenes as Amide Isopolar Mimics

Eeda, V.; Selvaraju, M.; Altman, R. A.*

J. Fluorine Chem. 2019, 218, 90–98.

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Fluorination in Medicinal Chemistry, Medicinal and Biological Chemistry, Pre 2020, Delta Opioid Receptor Altmaniacs 6/14/24 Fluorination in Medicinal Chemistry, Medicinal and Biological Chemistry, Pre 2020, Delta Opioid Receptor Altmaniacs 6/14/24

28. Tyr1-ψ[(Z)CF═CH]-Gly2 Fluorinated Peptidomimetic Improves Distribution and Metabolism Properties of Leu-Enkephalin

Altman, R. A.*; Sharma, K. K.; Rajewski, L. G.; Toren, P. C.; Baltezor, M. J.; Pal, M.; Karad, S. N.

ACS Chem. Neurosci. 2018, 9, 1735–1742.

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Medicinal and Biological Chemistry, Pre 2020, Kynurenine Pathway Altmaniacs 6/14/24 Medicinal and Biological Chemistry, Pre 2020, Kynurenine Pathway Altmaniacs 6/14/24

27. Stepwise O-Atom Transfer in Heme-based Tryptophan Dioxygenase: The Role of Substrate Ammonium in the Epoxide Ring Opening

Shin, I.; Ambler, B. R.; Wherritt, D.; Griffith, W.; Maldonado, A.; Altman, R. A.;* Liu, A.*

J. Am. Chem. Soc. 2018, 140, 4372–4379.

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