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Synthetic Fluorination Methodology
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Graduate and Postdoctoral Work
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Ryan Altman
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Synthetic Fluorination Methodology
Medicinal and Biological Chemistry
Folder: Publications
Back
All Publications
Synthetic Organic Methodology
Medicinal and Biological Chemistry
Reviews
Graduate and Postdoctoral Work
Book Chapters and Minor Works
Ryan Altman
Our Team
Links
2020 to Present, Synthetic Organic Methodology, Aromatization Altmaniacs 9/9/26 2020 to Present, Synthetic Organic Methodology, Aromatization Altmaniacs 9/9/26

66. Deoxytrifluoromethylation/Aromatization to Access Highly Substituted Fluoroalkyl Arenes Under Milder Aromatization Conditions

Bhattarai, P. B.; Zhao, A. Y.; Wise, J. W.; Cowper, N. G. W.; Gilbert, M. M.; Morrill, W. H.; Tao, D. J.; Goel K.; Altman, R. A.*

Manuscript Submitted.

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2020 to Present, Synthetic Organic Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling Altmaniacs 9/9/26 2020 to Present, Synthetic Organic Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling Altmaniacs 9/9/26

64. Palladium-Catalyzed Base-Controlled para-Selective C–H Functionalization of Arenes

Intelli, A. J.; Wayment, C. J.; Selvaraju, M.; Altman, R. A.*

Manuscript Submitted.

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2020 to Present, Fluorinated Alkenes, Synthetic Organic Methodology, Organofluorine Methodology Altmaniacs 12/30/25 2020 to Present, Fluorinated Alkenes, Synthetic Organic Methodology, Organofluorine Methodology Altmaniacs 12/30/25

60. Selenide-Enabled Photocatalytic Hydroazolation of gem-Difluoroalkenes

Abd El Gaber M. K.; Herrick, R.; Sudhakar, P.; Rana, A.; Roach, B. A.; Dick, J. E.; Altman, R. A.*

Chem. Sci. 2025, 16, 22701–22710.

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2020 to Present, Synthetic Organic Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Organofluorine Methodology, Aromatization Altmaniacs 9/12/25 2020 to Present, Synthetic Organic Methodology, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Organofluorine Methodology, Aromatization Altmaniacs 9/12/25

59. Insights into Deoxytrifluoromethylation /Aromatization to Access Highly Substituted Trifluoromethyl Arenes

Bhattarai, P.; Abd El-Gaber, M. K.; Koley, S.K.; Altman, R. A.*

J. Org. Chem. 2025, 90, 14291–14303.

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2020 to Present, Delta Opioid Receptor, Synthetic Organic Methodology, Medicinal and Biological Chemistry Altmaniacs 8/1/25 2020 to Present, Delta Opioid Receptor, Synthetic Organic Methodology, Medicinal and Biological Chemistry Altmaniacs 8/1/25

58. Unified Enantioselective Synthesis of 5-Phenylmorphans and cis-Octahydroisoquinolines

Mahgoub, A.; Khamrai, J.; Festus, O.; Altman, R. A.*

Org. Lett. 2025, 27, 8941–8945.

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2020 to Present, Synthetic Organic Methodology Altmaniacs 8/1/25 2020 to Present, Synthetic Organic Methodology Altmaniacs 8/1/25

57. NBS-Promoted Synthesis of Maleimides by Oxidative Dearomatization of Pyrroles: Mechanistic Investigations Using Online MS in Real-Time

Kumar, A.; Mishra, P. K.; Nandy, A.; Altman, R. A.; Banerjee, S.; Verma, A. K.*

Org. Lett. 2025, 27, 7810–7815.

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2020 to Present, Deoxyfluoroalkylation, Organofluorine Methodology, Synthetic Organic Methodology, Aromatization Altmaniacs 1/8/25 2020 to Present, Deoxyfluoroalkylation, Organofluorine Methodology, Synthetic Organic Methodology, Aromatization Altmaniacs 1/8/25

55. A Deoxyfluoroalkylation-Aromatization Strategy to Access Fluoroalkyl Arenes

Bhattarai, P.; Koley, S. K.; Goel, K.; Altman, R. A.*

Chem. Commun. 2025, 61, 2524–2527.

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Fluorinated Alkenes, Synthetic Organic Methodology, 2020 to Present, Organofluorine Methodology, Deoxyfluoroalkylation Altmaniacs 1/2/25 Fluorinated Alkenes, Synthetic Organic Methodology, 2020 to Present, Organofluorine Methodology, Deoxyfluoroalkylation Altmaniacs 1/2/25

54. Synthesis of 4-(2,2-Difluorovinyl)benzonitrile through a Wittig-type Olefination of 4-Formylbenzonitrile

Intelli. A. J.; Sorrentino, J. P.; Altman, R. A.*

Org. Synth. 2024, 101, 542.

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Organofluorine Methodology, Synthetic Organic Methodology, Fluorinated Alkenes, 2020 to Present Altmaniacs 10/1/24 Organofluorine Methodology, Synthetic Organic Methodology, Fluorinated Alkenes, 2020 to Present Altmaniacs 10/1/24

51. Palladium and Copper Co-Catalyzed Chloro-Arylation of gem-Difluorostyrenes – Use of a Nitrite Additive to Suppress β-F Elimination

Intelli, A. J.; Wayment, C. Z.; Lee, R. T.; Yuan, K.; Altman, R. A.*

Chem. Sci. 2024, 15, 17571–17578.

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Synthetic Organic Methodology, Deoxyfluoroalkylation, Aromatization, 2020 to Present, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Organofluorine Methodology Altmaniacs 8/28/24 Synthetic Organic Methodology, Deoxyfluoroalkylation, Aromatization, 2020 to Present, Decarboxylative and Deoxygenative Fluoroalkylation Coupling, Organofluorine Methodology Altmaniacs 8/28/24

50. Deoxytrifluoromethylation/Aromatization of Cyclohexan(en)ones to Access Highly Substituted Trifluoromethylarenes

Bhattarai, P.; Abd El-Gaber, M. K.; Koley, S. K.; Altman, R. A.* 

Nature Commun. 2024, 15, 7882.

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Fluorinated Alkenes, Synthetic Organic Methodology, Organofluorine Methodology, 2020 to Present Altmaniacs 6/17/24 Fluorinated Alkenes, Synthetic Organic Methodology, Organofluorine Methodology, 2020 to Present Altmaniacs 6/17/24

49. Peroxide-Initiated Hydrophosphination of gem-Difluoroalkenes

Intelli, A. J.; Lee, R. T.; Altman, R. A.*

J. Org. Chem. 2023, 88, 14012–14021.

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Synthetic Organic Methodology, Organofluorine Methodology, 2020 to Present Altmaniacs 6/17/24 Synthetic Organic Methodology, Organofluorine Methodology, 2020 to Present Altmaniacs 6/17/24

48. Palladium-Catalyzed Dearomatization of Benzothiophenes: Isolation and Functionalization of a Discrete Dearomatized Intermediate

Intelli, A. J.; Pal, M.; Selvaraju, M.; Altman, R. A.*

Synthesis 2023, 55, 3568–3574.

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Fluorinated Alkenes, Organofluorine Methodology, Synthetic Organic Methodology, 2020 to Present Altmaniacs 6/17/24 Fluorinated Alkenes, Organofluorine Methodology, Synthetic Organic Methodology, 2020 to Present Altmaniacs 6/17/24

47. A Diselenide Additive Enables Photocatalytic Hydroalkoxylation of gem-Difluoroalkenes

Herrick, R. M.; Abd El-Gaber, M. K.; Rodriguez, L. G. C.; Altman, R. A.*

Chem. Commun. 2023, 59, 5623–5626.

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Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/17/24 Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/17/24

46. Photocatalytic Hydrothiolation of gem-Difluoroalkenes

Sorrentino, J. P.; Herrick, R. M.; Abd El-Gaber, M. K.; Abdelazem, A. Z.; Altman, R. A.*

J. Org. Chem. 2022, 87, 16676–16690.

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Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/17/24 Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/17/24

45. Cu(II)-Catalyzed Oxidation of gem-Difluoroalkenes Generate α,α-Difluorinated-α-Phenoxyketones

Koley, S.; Cayton, K. T.; González-Montiel, G. A.; Yadav, M. R.; Orsi, D. L.; Intelli, A. J.; Cheong, P. H.-Y.;* Altman, R. A.*

J. Org. Chem. 2022, 87, 10710–10725.

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Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology, Reviews Altmaniacs 6/17/24 Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology, Reviews Altmaniacs 6/17/24

42. Fluorine-Retentive Strategies for the Functionalization of gem-Difluoroalkenes

Sorrentino, J. P.; Altman, R. A.*

Synthesis 2021, 53, 3935–3950.

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Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24 Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24

41. Acid-catalyzed Hydrothiolation of gem-Difluorostyrenes to Access α,α-Difluoroalkylthioethers

Sorrentino, J. P.; Orsi, D. L.; Altman, R. A.*

J. Org. Chem. 2021, 86, 2297–2311.

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Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24 Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24

39. Arylation of gem-difluoroalkenes using a Pd/Cu Co-catalytic system that avoids β-fluoride elimination

Yuan, K.; Feoktistova, T.; Cheong, P. H.-Y.;* Altman, R. A.*

Chem. Sci. 2021, 12, 1363–1367.

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Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24 Fluorinated Alkenes, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24

38. Cobalt-Catalyzed Selective Unsymmetric Dioxidation of β,β-Difluorostyrenes

Orsi, D. L.; Sorrentino, J. P.; Douglas, J. T.; Altman, R. A.*

J. Org. Chem. 2020, 85, 10451–10465.

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Fluorinated Alkenes, Reviews, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24 Fluorinated Alkenes, Reviews, Organofluorine Methodology, 2020 to Present, Synthetic Organic Methodology Altmaniacs 6/14/24

36. Recent Advances in Transition Metal Catalyzed Functionalization of gem-Difluoroalkenes

Koley, S.; Altman, R. A.*

Isr. J. Chem. 2020, 60, 313–339.

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