Medicinal and Biological Chemistry

Kynurenine Pathway
Delta Opioid Receptor
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62. The Effect of N-Alkyl Azole Difluorination on Molecular Properties Relevant for Lead Optimization: A Comparative Study
62. The Effect of N-Alkyl Azole Difluorination on Molecular Properties Relevant for Lead Optimization: A Comparative Study

Herrick, R. M.; Green, S. A.; Rich, S.; Grandner, J. N.; Huard, K.;* Altman, R. A.*

ACS Med. Chem. Lett. 2026, 17, 721–726.

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61. On the Metabolic Stability of Fluorinated Small Molecules: A Physical Organic Chemistry Perspective
61. On the Metabolic Stability of Fluorinated Small Molecules: A Physical Organic Chemistry Perspective

Bhattarai, P. B.; Trombley, T. A.; Altman, R. A.*

J. Med. Chem. 2026, 69, 1916–1941.

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44. Fluoroalkylation of Dextromethorphan Improves CNS Exposure and Metabolic Stability
44. Fluoroalkylation of Dextromethorphan Improves CNS Exposure and Metabolic Stability

Sorrentino, J. P.; Altman, R. A.*

ACS Med. Chem. Lett. 2022, 13, 707–713.

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43. Modulating β-Arrestin-2 Recruitment at the δ- and μ-Opioid Receptors
43. Modulating β-Arrestin-2 Recruitment at the δ- and μ-Opioid Receptors

Sharma K. S.; Cassell, R. J.; Meqbil, Y. J.; Su, H.; Blaine, A. T.; Cummins, B. R.; Mores, K. L.; Johnson, D.; van Rijn, R. M.;* Altman, R. A.*

RSC Med. Chem. 2021, 12, 1958–1967.

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37. Late-Stage Conversion of a Metabolically Labile Aryl Methyl Ether-Containing Natural Product to Fluoroalkyl Analogues
37. Late-Stage Conversion of a Metabolically Labile Aryl Methyl Ether-Containing Natural Product to Fluoroalkyl Analogues

Sorrentino, J. S.; Ambler, B. R.; Altman, R. A.*

J. Org. Chem. 2020, 85, 5416–5427.

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29. Synthesis of Leu-Enkephalin Peptidomimetics Containing Trifluromethylalkenes as Amide Isopolar Mimics
29. Synthesis of Leu-Enkephalin Peptidomimetics Containing Trifluromethylalkenes as Amide Isopolar Mimics

Eeda, V.; Selvaraju, M.; Altman, R. A.*

J. Fluorine Chem. 2019, 218, 90–98.

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28. Tyr1-ψ[(Z)CF═CH]-Gly2 Fluorinated Peptidomimetic Improves Distribution and Metabolism Properties of Leu-Enkephalin
28. Tyr1-ψ[(Z)CF═CH]-Gly2 Fluorinated Peptidomimetic Improves Distribution and Metabolism Properties of Leu-Enkephalin

Altman, R. A.*; Sharma, K. K.; Rajewski, L. G.; Toren, P. C.; Baltezor, M. J.; Pal, M.; Karad, S. N.

ACS Chem. Neurosci. 2018, 9, 1735–1742.

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24. Synthesis and Opioid Activity of Tyr1–ψ[(Z)CF=CH]–Gly2 and Tyr1–ψ[(S)/(R)-CF3CH–NH]–Gly2 Leu-enkephalin Fluorinated Peptidomimetics
24. Synthesis and Opioid Activity of Tyr1–ψ[(Z)CF=CH]–Gly2 and Tyr1–ψ[(S)/(R)-CF3CH–NH]–Gly2 Leu-enkephalin Fluorinated Peptidomimetics

Karad, S. N.; Pal, M.; Crowley, R. S.; Prisinzano, T. E.; Altman, R. A.*

ChemMedChem 2017, 12, 571–576.

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Kynurenine Pathway
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