Publications

  • 44. Fluoroalkylation of Dextromethorphan Improves CNS Exposure and Metabolic Stability

    Sorrentino, J.; Altman, R. A.*

    ACS Med. Chem. Lett. 2022, 13, 707–713.

    Medicinal Chemistry, Fluorination in Medicinal Chemistry

  • 43. Modulating β-Arrestin-2 Recruitment at the δ- and μ-Opioid Receptors

    Sharma K. S.; Cassell, R. J.; Meqbil, Y. J.; Su, H.; Blaine, A. T.; Cummins, B. R.; Mores, K. L.; Johnson, D.; van Rijn, R. M.;* Altman, R. A.*

    RSC Med. Chem. 2021, 12, 1958–1967.

    Medicinal Chemistry, Delta Opioid Receptor, Fluorination in Medicinal Chemistry

  • 40. Diflunisal Derivatives as Modulators of ACMS Decarboxylase Targeting the Tryptophan-Kynurenine Pathway

    Yang, Y.; Borel, T.; de Azambuja, F.; Johnson, D.; Sorrentino, J. P.; Udokwu, C.; Davis, I.; Liu, A.;* Altman, R. A.*

    J. Med. Chem. 2021, 64, 797–811.

    Medicinal Chemistry, Fluorination in Medicinal Chemistry, Kynurenine Pathway

  • 37. Late-Stage Conversion of a Metabolically Labile Aryl Methyl Ether-Containing Natural Product to Fluoroalkyl Analogues

    Sorrentino, J. S.; Ambler, B. R.; Altman, R. A.*

    J. Org. Chem. 2020, 85, 5416–5427.

    Medicinal Chemistry, Fluorination in Medicinal Chemistry

  • 34. The Meta-Position of Phe4 in Leu-enkephalin Regulates Potency, Selectivity, Functional Activity, and Signaling Bias at the Delta and Mu Opioid Receptors

    Cassell, R. J.; Sharma K. S.; Su, H.; Cummins, B. R.; Cui, H.; Mores, K. L.; Blaine, A. T.; Altman, R. A.;* van Rijn, R. M.*

    Molecules 2019, 24, 4542.

    Medicinal Chemistry, Delta Opioid Receptor

  • 29. Synthesis of Leu-Enkephalin Peptidomimetics Containing Trifluromethylalkenes as Amide Isopolar Mimics

    Eeda, V.; Selvaraju, M.; Altman, R. A.*

    J. Fluorine Chem. 2019, 218, 90–98.

    Medicinal Chemistry, Fluorination in Medicinal Chemistry

  • 28. Tyr1-ψ[(Z)CF═CH]-Gly2 Fluorinated Peptidomimetic Improves Distribution and Metabolism Properties of Leu-Enkephalin

    Altman, R. A.;* Sharma, K. K.; Rajewski, L. G.; Toren, P. C.; Baltezor, M. J.; Pal, M.; Karad, S. N.

    ACS Chem. Neurosci. 2018, 9, 1735–1742.

    Medicinal Chemistry, Fluorination in Medicinal Chemistry

  • 27. Stepwise O-Atom Transfer in Heme-based Tryptophan Dioxygenase: The Role of Substrate Ammonium in the Epoxide Ring Opening

    Shin, I.; Ambler, B. R.; Wherritt, D.; Griffith, W.; Maldonado, A.; Altman, R. A.; Liu, A.*

    J. Am. Chem. Soc. 2018, 140, 4372–4379.

    Medicinal Chemistry

  • 24. Synthesis and Opioid Activity of Tyr1–ψ[(Z)CF=CH]–Gly2 and Tyr1–ψ[(S)/(R)-CF3CH–NH]–Gly2 Leu-enkephalin Fluorinated Peptidomimetics

    Karad, S. N.; Pal, M.; Crowley, R. S.; Prisinzano, T. E.; Altman, R. A.*

    ChemMedChem 2017, 12, 571–576.

    Medicinal Chemistry, Fluorination in Medicinal Chemistry

  • 16. Decarboxylative Fluorination Strategies for Accessing Medicinally-Relevant Products

    Qiao, Y.; Ambler, B. R.; Zhu, L.; Altman, R. A.*

    Curr. Top. Med. Chem. 2014, 14, 966–978.

    Synthetic Fluorination Methodology, Decarboxylative Coupling, Medicinal Chemistry, Fluorination in Medicinal Chemistry, Reviews