https://www.altmaniacs.com/blog-2-1 daily 0.75 2026-08-25 https://www.altmaniacs.com/blog-2-1/62-the-effect-of-n-alkyl-azole-difluorination-on-molecular-properties-relevant-for-lead-optimization-a-comparative-study monthly 0.5 2026-04-20 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/93662d80-03e8-48ca-b73e-486280643fe7/62+ACS+MCL+Azole+N-Alkylfluorination Publications - 62. The Effect of N-Alkyl Azole Difluorination on Molecular Properties Relevant for Lead Optimization: A Comparative Study - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/60-on-the-metabolic-stability-of-fluorinated-small-molecules-a-physical-organic-chemistry-perspective-ltd3d monthly 0.5 2026-04-20 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/b9eb3247-3397-4000-b7e2-b7555c096527/Metabolism+TOC+%284%29.png Publications - 61. On the Metabolic Stability of Fluorinated Small Molecules: A Physical Organic Chemistry Perspective - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/60-selenide-enabled-photocatalytic-hydroazolation-of-gem-difluoroalkenes monthly 0.5 2026-04-20 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/b946c0fe-d018-4681-8bed-7d7e9e58e975/60+DFA+Hydroazolation.png Publications - 60. Selenide-Enabled Photocatalytic Hydroazolation of gem-Difluoroalkenes - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/59 monthly 0.5 2026-04-20 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/d34b534b-68e8-44d9-9075-8ff0abe81555/6X+Insights+Deoxytrifluoromethylation-Aromatization+TOC.png Publications - 59. Insights into Deoxytrifluoromethylation /Aromatization to Access Highly Substituted Trifluoromethyl Arenes - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/57-unified-enantioselective-synthesis-of-5-phenylmorphans-and-cis-octahydroisoquinolines monthly 0.5 2026-04-20 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/3da7c95c-06f8-46d1-a9d3-70ad1a41393e/images_large_ol5c02600_0005.jpeg Publications - 58. Unified Enantioselective Synthesis of 5-Phenylmorphans and cis-Octahydroisoquinolines - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/58-nbs-promoted-synthesis-of-maleimides-by-oxidative-dearomatization-of-pyrroles-mechanistic-investigations-using-online-ms-in-real-time monthly 0.5 2026-04-20 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/3653ffe6-78a3-4316-8ca6-62f442e6dbdf/5X+Pyrroles+to+Maleimides.png Publications - 57. NBS-Promoted Synthesis of Maleimides by Oxidative Dearomatization of Pyrroles: Mechanistic Investigations Using Online MS in Real-Time - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/56-discovery-of-rgs2-fbxo44-interaction-inhibitors-using-a-cell-based-nanobit-assay monthly 0.5 2026-04-20 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/eaccbf23-4085-4394-ba41-2e818996e008/56+TAR.png Publications - 56. Discovery of RGS2-FBXO44 interaction inhibitors using a cell-based NanoBit assay - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/55-a-deoxyfluoroalkylation-aromatization-strategy-to-access-fluoroalkyl-arenes monthly 0.5 2026-04-20 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/5888ccfb-c966-420f-82c8-d3cf34eb9879/55+Deoxyfluoroalkylation+ChemComm+TOC+1.png Publications - 55. A Deoxyfluoroalkylation-Aromatization Strategy to Access Fluoroalkyl Arenes - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/54-synthesis-of-4-22-difluorovinylbenzonitrile-through-a-wittig-type-olefination-of-4-formylbenzonitrile monthly 0.5 2026-04-20 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/850a2334-6564-4d88-964f-acc39c640f9c/54.png Publications - 54. Synthesis of 4-(2,2-Difluorovinyl)benzonitrile through a Wittig-type Olefination of 4-Formylbenzonitrile - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/53-a-phenotypic-high-throughput-screen-identifies-small-molecule-modulators-of-endogenous-rgs10-in-bv-2-cells monthly 0.5 2026-08-06 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/0ab4ff73-0a50-432f-8197-a4a369daddca/A+Phenotypic+High-Throughput+Screen+Identifies+Small+Molecule+Modulators+of+Endogenous+RGS10+in+BV-2+Cells+TOC+Figure.jpeg Publications - 53. A Phenotypic High-Throughput Screen Identifies Small Molecule Modulators of Endogenous RGS10 in BV-2 Cells - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/52-amino-carboxymuconate-semialdehyde-decarboxylase-catalyzes-enolketo-tautomerization-of-oxaloacetate monthly 0.5 2026-04-20 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/1038679c-1ea5-43de-9506-92a37b46f6b1/52.jpg Publications - 52. α-Amino-β-Carboxymuconate-ε-Semialdehyde Decarboxylase Catalyzes Enol/Keto Tautomerization of Oxaloacetate - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/51-palladium-and-copper-co-catalyzed-chloro-arylation-of-gem-difluorostyrenes-use-of-a-nitrite-additive-to-suppress-f-elimination monthly 0.5 2026-04-20 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/1204a8ac-24d0-4d7e-bca7-eb02d62bc71f/51+-+Chem+Sci+Chloro+Arylation+of+DFA+TOC.png Publications - 51. Palladium and Copper Co-Catalyzed Chloro-Arylation of gem-Difluorostyrenes – Use of a Nitrite Additive to Suppress β-F Elimination - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/50-deoxytrifluoromethylationaromatization-of-cyclohexanenones-to-access-highly-substituted-trifluoromethylarenes monthly 0.5 2025-12-04 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/4392dafd-b19e-45ff-9d9a-e722c4bae0ae/50+Deoxytrifluoromethylation+Aromatization+TOC.png Publications - 50. Deoxytrifluoromethylation/Aromatization of Cyclohexan(en)ones to Access Highly Substituted Trifluoromethylarenes - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/49 monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/aadebc9b-5e6b-41f1-a4a6-129b1921476d/49+Hydrophosphination+TOC.png Publications - 49. Peroxide-Initiated Hydrophosphination of gem-Difluoroalkenes https://www.altmaniacs.com/blog-2-1/blog-post-title-two-4kb9p-h6tgg monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/d8388ab1-b990-485e-9dd5-9c8dfd29b52b/48+Dearom+Chemdraw+TOC.png Publications - 48. Palladium-Catalyzed Dearomatization of Benzothiophenes: Isolation and Functionalization of a Discrete Dearomatized Intermediate - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/blog-post-title-three-mfpc9-hstj9 monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/d0865eaf-98d8-433e-8987-06d2c89e8134/47+Fluoroalkene+Hydroalkoxylation.png Publications - 47. A Diselenide Additive Enables Photocatalytic Hydroalkoxylation of gem-Difluoroalkenes - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/blog-post-title-four-cxpt7-w934c monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/0e3fac2f-3073-4218-968f-61a92f420735/MicrosoftTeams-image+%2811%29.png Publications - 46. Photocatalytic Hydrothiolation of gem-Difluoroalkenes - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/45-cuii-catalyzed-oxidation-of-gem-difluoroalkenes-generate-difluorinated-phenoxyketones monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/e3d62187-0e31-448a-804a-bdde9c30b62f/MicrosoftTeams-image+%2810%29.png Publications - 45. Cu(II)-Catalyzed Oxidation of gem-Difluoroalkenes Generate α,α-Difluorinated-α-Phenoxyketones - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/44-fluoroalkylation-of-dextromethorphan-improves-cns-exposure-and-metabolic-stability monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/e6e56c08-d757-48d4-aa6d-4b992b77d581/MicrosoftTeams-image+%289%29.png Publications - 44. Fluoroalkylation of Dextromethorphan Improves CNS Exposure and Metabolic Stability - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/43-modulating-arrestin-2-recruitment-at-the-and-opioid-receptors monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/2939f91f-32bc-449f-9781-b2382b2d5bf8/MicrosoftTeams-image+%288%29.png Publications - 43. Modulating β-Arrestin-2 Recruitment at the δ- and μ-Opioid Receptors - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/42-fluorine-retentive-strategies-for-the-functionalization-of-gem-difluoroalkenes-1 monthly 0.5 2026-04-13 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/c39972aa-8d51-4797-8fef-de3d1cc5ff32/i_r0281_ga_10-1055_a-1547-9270.gif Publications - 42. Fluorine-Retentive Strategies for the Functionalization of gem-Difluoroalkenes - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/41-acid-catalyzed-hydrothiolation-of-gem-difluorostyrenes-to-access-difluoroalkylthioethers monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/0f6ec96b-8d0d-445c-8d7a-2867af6f72b6/41+FEM+%2B+HSAlkyl.png Publications - 41. Acid-catalyzed Hydrothiolation of gem-Difluorostyrenes to Access α,α-Difluoroalkylthioethers - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/40-diflunisal-derivatives-as-modulators-of-acms-decarboxylase-targeting-the-tryptophan-kynurenine-pathway monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/44494643-073d-4446-89ce-b960616dce0e/40+ACMSD+Inhibitors.jpeg Publications - 40. Diflunisal Derivatives as Modulators of ACMS Decarboxylase Targeting the Tryptophan-Kynurenine Pathway - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/39-arylation-of-gem-difluoroalkenes-using-a-pdcu-co-catalytic-system-that-avoids-fluoride-elimination monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/36a583b5-7dd2-4d50-884e-1afb7337059f/39+Pd-Cat+DFA+Arylation-Isomerization.png Publications - 39. Arylation of gem-difluoroalkenes using a Pd/Cu Co-catalytic system that avoids β-fluoride elimination - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/38-cobalt-catalyzed-selective-unsymmetric-dioxidation-of-difluorostyrenes monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/2412bfa5-5085-48c5-abd2-8269bca9373e/38+Co+DFA+Difunctionalization+TOC.png Publications - 38. Cobalt-Catalyzed Selective Unsymmetric Dioxidation of β,β-Difluorostyrenes - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/37-late-stage-conversion-of-a-metabolically-labile-aryl-methyl-ether-containing-natural-product-to-fluoroalkyl-analogues monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/ffd005b3-d972-470c-bc2b-10921b558c36/37+DXM+Synthesis.png Publications - 37. Late-Stage Conversion of a Metabolically Labile Aryl Methyl Ether-Containing Natural Product to Fluoroalkyl Analogues - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/36-recent-advances-in-transition-metal-catalyzed-functionalization-of-gem-difluoroalkenes monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/b601fec8-be48-4662-b573-35f532822d68/36+TM-DFA+IJC+Review.png Publications - 36. Recent Advances in Transition Metal Catalyzed Functionalization of gem-Difluoroalkenes - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/35-connecting-remote-ch-bond-functionalization-and-decarboxylative-coupling-using-simple-amines monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/5f63d07a-0b60-459d-b9d0-bf0f76945251/35+Pd-cat+para-Selective+C%CE%93%C3%87%C3%B4H+Functionalization.png Publications - 35. Connecting Remote C–H Bond Functionalization and Decarboxylative Coupling Using Simple Amines - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/34-the-meta-position-of-phe4-in-leu-enkephalin-regulates-potency-selectivity-functional-activity-and-signaling-bias-at-the-delta-and-mu-opioid-receptors monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/b435a46d-a8c9-4c25-b18e-873a1288d2ed/34+ACS+CN+Phe4+Leu-Enk.png Publications - 34. The Meta-Position of Phe4 in Leu-enkephalin Regulates Potency, Selectivity, Functional Activity, and Signaling Bias at the Delta and Mu Opioid Receptors - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/33-bbdfa-a-practical-reagent-for-trifluoromethylation-of-allylic-and-benzylic-alcohols-on-preparative-scale monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/a657847e-f2b3-4ea2-82d2-9568d357d49c/33+OPRD+BBDFA+Trifluoromethylation.png Publications - 33. BBDFA: A Practical Reagent for Trifluoromethylation of Allylic and Benzylic Alcohols on Preparative Scale - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/32-organocatalytic-strategy-for-hydrophenolation-of-gem-difluoroalkenes monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/e6fba0be-5439-4af7-aea4-d8d9d4c947f9/32+Tetrahedron+Difluoroalkene+Hydrophenolation+TOC.png Publications - 32. Organocatalytic Strategy for Hydrophenolation of gem-Difluoroalkenes - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/31-synthesis-of-c2-deutero-l-tryptophan-by-sequential-ir-catalyzed-reactions monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/10cfbbe1-b303-4b90-ab8b-4859093d1340/31+2-D-L-Tryptphan+TOC.png Publications - 31. Synthesis of C2-Deutero-L-Tryptophan by Sequential Ir-Catalyzed Reactions - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/30-catalytic-one-step-deoxytrifluoromethylation-of-alcohols monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/18bddfb9-2f1e-4452-9152-fdb5fccb84da/30+JOC+Deoxytrifluoromethylation.png Publications - 30. Catalytic One-Step Deoxytrifluoromethylation of Alcohols - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/29-synthesis-of-leu-enkephalin-peptidomimetics-containing-trifluromethylalkenes-as-amide-isopolar-mimics monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/e6b9fae2-5335-48f1-8ed0-757e0c533bc3/29+JFC+%28CF3%3DCH%29Enkephalin.png Publications - 29. Synthesis of Leu-Enkephalin Peptidomimetics Containing Trifluromethylalkenes as Amide Isopolar Mimics - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/28-tyr1-zcfch-gly2-fluorinated-peptidomimetic-improves-distribution-and-metabolism-properties-of-leu-enkephalin monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/5bc3243d-2f1b-45a7-bcf5-df5ac72dede1/28+ACS+Chem+Neurosci+FPM+DMPK.png Publications - 28. Tyr1-ψ[(Z)CF═CH]-Gly2 Fluorinated Peptidomimetic Improves Distribution and Metabolism Properties of Leu-Enkephalin - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/27-stepwise-o-atom-transfer-in-heme-based-tryptophan-dioxygenase-the-role-of-substrate-ammonium-in-the-epoxide-ring-opening monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/738053b7-c018-4004-81bd-81bfcbbac609/27+JACS+TDO+Mechansim.png Publications - 27. Stepwise O-Atom Transfer in Heme-based Tryptophan Dioxygenase: The Role of Substrate Ammonium in the Epoxide Ring Opening - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/26-exploiting-the-unusual-effects-of-fluorine-in-methodology monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/c0b92ea7-0ef3-427c-86bf-8c6edeec86f4/26+ChemComm+Review.jpg Publications - 26. Exploiting the Unusual Effects of Fluorine in Methodology - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/25-base-catalysis-enables-access-to-difluoroalkylthio-ethers monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/02b783fc-dfcf-42ae-bda8-0a7c411d9087/25+OL+difluoroalkylthioethers.png Publications - 25. Base Catalysis Enables Access to α,α-Difluoroalkylthio-ethers - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/24-synthesis-and-opioid-activity-of-tyr1zcfchgly2-and-tyr1sr-cf3chnhgly2-leu-enkephalin-fluorinated-peptidomimetics monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/249ff4df-c978-4f0b-ae14-5492994b495e/24+ChemMedChem+Enkephalin+FPMs.png Publications - 24. Synthesis and Opioid Activity of Tyr1–ψ[(Z)CF=CH]–Gly2 and Tyr1–ψ[(S)/(R)-CF3CH–NH]–Gly2 Leu-enkephalin Fluorinated Peptidomimetics - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/23-metal-catalyzed-decarboxylative-fluoroalkylation-reactions monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/1fc68d0b-0d6d-4272-b0d2-85ba3536bed7/23+Synlett+Synpacts+Decarboxylative+Fluoroalkylation.png Publications - 23. Metal-catalyzed Decarboxylative Fluoroalkylation Reactions - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.altmaniacs.com/blog-2-1/22-palladium-catalysis-enables-benzylation-of-difluoroketone-enolates monthly 0.5 2025-09-12 https://images.squarespace-cdn.com/content/v1/615f42729a3e7155f1428c2e/7a1a8649-a9bf-4469-bcb3-e850b690a798/22+AICE+Benzyl+Difluoroketones-b.png Publications - 22. 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